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Updated: Aug 11, 2026
11:28
Analytical Techniques for Assaying Nitric Oxide Bioactivity
Published on: June 18, 2012
Summary
The development of nitrate drugs, like nitroglycerin and isosorbide dinitrate, spans over a century. These vital medications for heart conditions have evolved significantly, gaining widespread clinical acceptance.
Area of Science:
- Pharmacology
- Medical History
Background:
- Nitrate drugs, including glyceryl trinitrate (nitroglycerin) and amyl nitrite, have a long history in clinical medicine.
- Organic nitrates emerged in the 1930s, offering longer-acting alternatives.
Observation:
- Isosorbide dinitrate, developed in the mid-20th century, gained broad use but faced temporary skepticism due to metabolism concerns.
- Research identified isosorbide 5-mononitrate as an effective antianginal agent.
Findings:
- The efficacy of oral nitrates was questioned due to first-pass metabolism, impacting their popularity around 1970.
- Subsequent research and formulation development have led to the current worldwide acceptance of nitrate drugs.
Implications:
- Nitrate vasodilators remain crucial in managing cardiovascular conditions.
- Ongoing research into nitrate metabolism and delivery systems continues to refine their clinical application.
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