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Incomplete endothelialization of WatchmanTM Device: Predictors and Implications from Two Cases
Sharan Prakash Sharma1, David Singh2, Dean Nakamura1
1Kansas City Heart Rhythm Institute and Research Foundation, Overland Park, KS.
Left atrial appendage occlusion (LAAO) using Watchman devices may not always achieve complete endothelialization, even years post-procedure. These cases highlight potential complications like thrombus formation and the need for further research into LAAO healing.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Medical Device Technology
Background:
- Left atrial appendage occlusion (LAAO) is an alternative stroke risk reduction strategy for non-valvular atrial fibrillation patients unsuitable for oral anticoagulation.
- Current guidelines recommend 45 days of post-procedural anticoagulation after Watchman device implantation, assuming complete endothelialization.
- Evidence supporting this duration primarily comes from animal studies, with human data on endothelialization timelines and implications being less clear.
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