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Cost-effectiveness of community-based screening and treatment of moderate acute malnutrition in Mali
Sheila Isanaka1, Dale A Barnhart2, Christine M McDonald3
1Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Insights
Ready-to-use supplementary foods (RUSF) effectively reduce child mortality from moderate acute malnutrition (MAM). This cost-effective intervention offers significant health benefits for children under five.
Area of Science:
- Public Health
- Nutrition Science
- Health Economics
Background:
- Moderate acute malnutrition (MAM) significantly contributes to child mortality and morbidity globally.
- Effective treatment of MAM is crucial to prevent progression to severe acute malnutrition and reduce child deaths.
Purpose of the Study:
- To evaluate the health outcomes, costs, and cost-effectiveness of four dietary supplements for MAM treatment in children aged 6-35 months in Mali.
- To compare ready-to-use supplementary foods (RUSF), corn-soy blend (CSB++), Misola (MI), and locally milled flour (LMF) for MAM management.
Main Methods:
- A cluster-randomised trial was conducted to assess nutritional outcomes of different MAM treatments.
- A decision tree model was employed to estimate long-term health outcomes and calculate incremental cost-effectiveness ratios (ICERs).
Main Results:
- MAM treatment with RUSF, CSB++, MI, and LMF reduced mortality risk by 15.4%, 12.7%, 11.9%, and 10.3%, respectively, compared to no treatment.
- The ICER for RUSF was US$9821 per death averted and US$347 per DALY averted, indicating favorable cost-effectiveness.
Conclusions:
- Treatment of moderate acute malnutrition with RUSF is a cost-effective strategy.
- RUSF demonstrates cost-effectiveness across various willingness-to-pay thresholds, making it a viable option for MAM intervention.
Introduction:
Moderate acute malnutrition (MAM) causes substantial child morbidity and mortality, accounting for 4.4% of deaths and 6.0% of disability-adjusted life years (DALY) lost among children under 5 each year. There is growing consensus on the need to provide appropriate treatment of MAM, both to reduce associated morbidity and mortality and to halt its progression to severe acute malnutrition. We estimated health outcomes, costs and cost-effectiveness of four dietary supplements for MAM treatment in children 6-35 months of age in Mali.
Methods:
We conducted a cluster-randomised MAM treatment trial to describe nutritional outcomes of four dietary supplements for the management of MAM: ready-to-use supplementary foods (RUSF; PlumpySup); a specially formulated corn-soy blend (CSB) containing dehulled soybean flour, maize flour, dried skimmed milk, soy oil and a micronutrient pre-mix (CSB++; Super Cereal Plus); Misola, a locally produced, micronutrient-fortified, cereal-legume blend (MI); and locally milled flour (LMF), a mixture of millet, beans, oil and sugar, with a separate micronutrient powder. We used a decision tree model to estimate long-term outcomes and calculated incremental cost-effectiveness ratios (ICERs) comparing the health and economic outcomes of each strategy.
Results:
Compared to no MAM treatment, MAM treatment with RUSF, CSB++, MI and LMF reduced the risk of death by 15.4%, 12.7%, 11.9% and 10.3%, respectively. The ICER was US$9821 per death averted (2015 USD) and US$347 per DALY averted for RUSF compared with no MAM treatment.
Conclusion:
MAM treatment with RUSF is cost-effective across a wide range of willingness-to-pay thresholds.
Trial Registration:
NCT01015950.
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