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Self-Assembled Thin-Layer Glycomaterials With a Proper Shell Thickness for Targeted and Activatable Cell Imaging.

Chao Zhang1, Guanzhen Wang2,3, Hai-Hao Han4

  • 1Emergency Department, Jinan Children's Hospital, Jinan, China.

Frontiers in Chemistry
|May 30, 2019
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Summary

Researchers developed a novel glycomaterial for precise disease diagnosis and therapy. This self-assembled material targets cell surface receptors and is activated by intracellular biothiols, enhancing theranostic capabilities.

Keywords:
activatablefluorescenceimagingprecisionreceptor

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Molecular Imaging

Background:

  • Targeted and activatable materials enhance disease diagnosis and therapy precision.
  • Current systems often target transmembrane antigens or release agents intracellularly.

Purpose of the Study:

  • To develop a self-assembled glycomaterial for targeted and activatable disease theranostics.
  • To create a material that targets transmembrane glycoprotein receptors and is activated by intracellular biothiols.

Main Methods:

  • Self-assembly of fluorescent glycoprobes with manganese dioxide.
  • Linking carbohydrate-targeting reagents and fluorophores via polyethylene glycol.
  • Investigating the role of shell thickness in biothiol-induced fluorescence activation.

Main Results:

  • A thin-layer glycomaterial was successfully synthesized.
  • The material demonstrated dual functionality: targeting cell surface receptors and fluorescence activation by intracellular biothiols.
  • Shell thickness was found to be critical for biothiol-induced fluorescence activation.

Conclusions:

  • The developed glycomaterial offers enhanced precision for disease theranostics.
  • This self-assembled system provides a new platform for targeted imaging and therapy.
  • Findings may guide the development of advanced self-assembled materials for precision medicine.