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Gold-Catalyzed Homogeneous (Cyclo)Isomerization Reactions
Marta Marín-Luna1, Olalla Nieto Faza1, Carlos Silva López1
1Departamento de Química Orgánica, Universidade de Vigo, Vigo, Spain.
Frontiers in Chemistry
|May 30, 2019
Summary
Gold catalysts efficiently mediate intramolecular cyclization and isomerization reactions of unsaturated compounds. This review highlights recent advances in gold-catalyzed transformations for synthesizing complex molecules, particularly those with allene or alkyne groups.
Area of Science:
- Organometallic Chemistry
- Organic Synthesis
- Catalysis
Background:
- Gold complexes are highly effective catalysts in organometallic chemistry due to their ability to activate unsaturated groups.
- Gold catalysts exhibit broad functional group tolerance and stability under various reaction conditions.
- Complex molecular architectures found in natural products and pharmaceuticals can be accessed through isomerization reactions.
Purpose of the Study:
- To review recent advancements in gold-catalyzed intramolecular (cyclo)isomerization reactions.
- To categorize these transformations based on substrate type and reaction mechanism.
- To showcase the utility of gold catalysis in generating molecular complexity.
Main Methods:
- Review of recent literature on gold(I)- and gold(III)-catalyzed reactions.
- Focus on intramolecular transformations involving allene and alkyne motifs.
- Classification of reactions by substrate and transformation type.
Main Results:
- Gold catalysts effectively promote a variety of intramolecular (cyclo)isomerization reactions.
- These reactions enable the construction of complex molecular scaffolds from simple precursors.
- Recent studies demonstrate the versatility of gold in mediating these transformations.
Conclusions:
- Gold catalysis is a powerful tool for synthesizing complex organic molecules.
- Intramolecular (cyclo)isomerization reactions catalyzed by gold are crucial for accessing valuable compounds.
- Continued research in gold catalysis promises further innovation in synthetic chemistry.
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