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Related Experiment Video

Updated: Jan 24, 2026

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
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White matter rather than gray matter damage characterizes essential tremor.

Sara Pietracupa1, Matteo Bologna1,2, Komal Bharti2

  • 1IRCCS Neuromed, Pozzilli (IS), Italy.

European Radiology
|May 30, 2019
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Summary

Essential tremor (ET) involves widespread gray and white matter changes in the brain, impacting both deep and upper brain structures. These changes correlate with tremor severity, cognitive issues, and depression.

Keywords:
Essential tremorGray matterMagnetic resonance imagingWhite matter

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Area of Science:

  • Neuroimaging
  • Neurology
  • Brain Anatomy

Background:

  • Essential tremor (ET) is a common neurological disorder characterized by involuntary shaking.
  • The underlying neurobiological mechanisms of ET, particularly gray matter (GM) and white matter (WM) alterations, require further investigation.

Purpose of the Study:

  • To investigate comprehensive changes in GM and WM in patients with ET.
  • To explore the relationship between these structural brain changes and clinical manifestations, including tremor severity, psychiatric symptoms, and cognitive impairment.

Main Methods:

  • A 3-Tesla MRI study including 3D-T1 and diffusion tensor imaging was conducted on 19 ET patients and 15 healthy subjects (HS).
  • GM analysis involved assessing cortical thickness, basal ganglia and thalamus volumes, and cerebellum lobular volumes.
  • WM integrity was evaluated using voxel-wise tract-based spatial statistics, and findings were correlated with clinical assessments.

Main Results:

  • ET patients exhibited significantly smaller right and left thalamic volumes compared to HS, correlating with cognitive scores.
  • No significant differences in cortical thickness or cerebellar lobular volumes were found between groups.
  • Widespread WM abnormalities were observed in various brain bundles, including the corticospinal tract and corpus callosum, correlating with tremor severity, cognitive function, and depression.

Conclusions:

  • Essential tremor is associated with significant GM and WM alterations in both infra- and supratentorial brain regions.
  • These structural changes provide insights into the mechanisms underlying motor and non-motor symptoms in ET.
  • The findings highlight the complex neurobiology of ET, involving widespread brain structural abnormalities.