Related Experiment Video
Updated: Jan 24, 2026
09:09
In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
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Laparoscopic versus open appendectomy for perforated appendicitis in adults: randomized clinical trial
Ahmed Talha1,2,3, Hany El-Haddad4,5,6, Abd-Elhamid Ghazal4,6
1Medical Research Institute, Alexandria University, 165, Horreya Avenue, Hadara, Alexandria, 21561, Egypt. ahmedtalha047@yahoo.com.
Surgical Endoscopy
|May 30, 2019
Summary
Laparoscopic appendectomy offers better outcomes for perforated appendicitis, including less pain and shorter hospital stays. Surgeons should consider laparoscopy for perforated appendicitis, managing potential complications with precautions.
Area of Science:
- Surgical innovation
- Gastrointestinal surgery
- Minimally invasive procedures
Background:
- Laparoscopic appendectomy acceptance lags for perforated appendicitis compared to uncomplicated cases.
- General surgical community's hesitation regarding laparoscopic approach for perforated appendicitis.
Purpose of the Study:
- To compare clinical outcomes of laparoscopic versus open appendectomy in perforated appendicitis.
- Evaluate the efficacy and safety of laparoscopic appendectomy in complex appendicitis cases.
Main Methods:
- Randomized controlled study involving 126 patients with perforated appendicitis.
- Comparison between 60 patients undergoing laparoscopic appendectomy (LA) and 66 patients undergoing open appendectomy (OA).
Main Results:
- Laparoscopic appendectomy showed significant advantages in reduced postoperative pain, decreased analgesic requirements, shorter hospital stays, and faster return to daily activities.
- Open appendectomy had a shorter mean operative time (94 min) compared to laparoscopic appendectomy (120.6 min).
- No significant difference in intra-abdominal collection rates between laparoscopic and open appendectomy groups.
Conclusions:
- Laparoscopic appendectomy is a viable and beneficial option for perforated appendicitis, supported by favorable clinical outcomes.
- Intra-abdominal collection risk should not deter the adoption of laparoscopy for perforated appendicitis with appropriate precautions.
- Encourages wider adoption of laparoscopic techniques by surgeons for perforated appendicitis.
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