Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to R01:11

Introduction to R

4.3K
R is a powerful software environment for statistical computing and graphics. Originating as an implementation of the S language, developed at Bell Laboratories, R has evolved into a robust, open-source statistical software favored by statisticians and data scientists worldwide. Its comprehensive suite includes data manipulation, calculation, and graphical display capabilities, making it versatile for data analysis and visualization. Its programming language is at the core of R's...
4.3K
Introduction to Virus01:28

Introduction to Virus

1.4K
Viruses are unique biological entities that blur the boundary between living and non-living systems. Although they lack cellular structure and metabolic processes, they can exhibit characteristics of life when infecting a host. Their defining feature is a nucleic acid core, composed of either DNA or RNA, encapsulated within a protein coat called a capsid. This simple structure allows them to invade host cells and use their machinery for replication efficiently.Viral Structure and...
1.4K
Introduction to Functional Groups02:08

Introduction to Functional Groups

35.0K

Functional groups are group of atoms with specific chemical properties that occur within organic molecules and sometimes denoted as “R”. Functional groups are found along the carbon backbone of macromolecules can form chains or rings of carbon atoms. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.  
Types of common functional groups
The table below summarizes some of the major functional groups in organic chemistry....
35.0K
Introduction to the Cytoskeleton01:33

Introduction to the Cytoskeleton

34.2K
Overview of the Cytoskeleton
The cytoskeleton is a network of protein filaments present within the cell, having three distinct filaments ̶   microfilaments, microtubules, and intermediate filaments. Each has characteristic features that distinguish them, including the dynamics of their assembly and disassembly, mechanical properties, polarity, and the type of molecular motors associated with them. Earlier, they were thought to be present only in eukaryotic cells; however, their...
34.2K
Introduction to Urinary System01:13

Introduction to Urinary System

8.7K
The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
8.7K
Tonsillitis I: Introduction01:30

Tonsillitis I: Introduction

2.0K
Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perioperative chemoimmunotherapy induces strong immune responses and long-term survival in patients with HLA class I-deficient non-small cell lung cancer.

Journal for immunotherapy of cancer·2024
Same author

The Challenges of HLA Class I Loss in Cancer Immunotherapy: Facts and Hopes.

Clinical cancer research : an official journal of the American Association for Cancer Research·2022
Same author

Copy Neutral LOH Affecting the Entire Chromosome 6 Is a Frequent Mechanism of <i>HLA</i> Class I Alterations in Cancer.

Cancers·2021
Same author

Study of HLA-A, -B, -C, -DRB1 and -DQB1 polymorphisms in COVID-19 patients.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi·2021
Same author

Tumor Escape Phenotype in Bladder Cancer Is Associated with Loss of HLA Class I Expression, T-Cell Exclusion and Stromal Changes.

International journal of molecular sciences·2021
Same author

MHC heterogeneity and response of metastases to immunotherapy.

Cancer metastasis reviews·2021
Same journal

Peptidomics in the Spotlight: Advanced Sample Treatment Techniques and Analytical Insights.

Advances in experimental medicine and biology·2026
Same journal

Methods for the Investigation of Protein-Ligands Interactions.

Advances in experimental medicine and biology·2026
Same journal

Sample Preparation Strategies for Microbial Cell Surface Proteomics: Integrating Shaving and Shotgun Approaches.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Sample Preparation for the Petroleum Industry: A Biocorrosion Case Study.

Advances in experimental medicine and biology·2026
Same journal

Proteomic and Functional Comparison of Extracellular Vesicles from Wild-Type and Lyn-Deficient Stromal Cells.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Analysis of Histone Sequence Variants and Post-translationally Modified Forms.

Advances in experimental medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Jan 24, 2026

A Microfluidic Chip for ICPMS Sample Introduction
11:16

A Microfluidic Chip for ICPMS Sample Introduction

Published on: March 5, 2015

11.7K

Introduction.

Federico Garrido1

  • 1Departamento de Analisis Clinicos e Inmunologia, Hospital Universitario Virgen de las Nieves, Facultad de Medicina, Universidad de Granada, Granada, Spain.

Advances in Experimental Medicine and Biology
|May 30, 2019
PubMed
Summary
This summary is machine-generated.

The discovery of the Major Histocompatibility Complex (MHC) and its role in tumor immunology is explored. Understanding MHC

Keywords:
Antigen processingBeta2 microglobulinH-2HLAHLA heavy chainHLA workshopsMHCMajor histocompatibility complexTumor escapeTumor immunology

More Related Videos

An Introduction to Worm Lab: from Culturing Worms to Mutagenesis
10:44

An Introduction to Worm Lab: from Culturing Worms to Mutagenesis

Published on: January 11, 2011

35.6K
Introduction to the Ultrasound Targeted Microbubble Destruction Technique
08:24

Introduction to the Ultrasound Targeted Microbubble Destruction Technique

Published on: June 12, 2011

16.0K

Related Experiment Videos

Last Updated: Jan 24, 2026

A Microfluidic Chip for ICPMS Sample Introduction
11:16

A Microfluidic Chip for ICPMS Sample Introduction

Published on: March 5, 2015

11.7K
An Introduction to Worm Lab: from Culturing Worms to Mutagenesis
10:44

An Introduction to Worm Lab: from Culturing Worms to Mutagenesis

Published on: January 11, 2011

35.6K
Introduction to the Ultrasound Targeted Microbubble Destruction Technique
08:24

Introduction to the Ultrasound Targeted Microbubble Destruction Technique

Published on: June 12, 2011

16.0K

Area of Science:

  • Immunology
  • Genetics

Background:

  • The discovery of the Major Histocompatibility Complex (MHC) in mice (H-2) and humans (HLA) laid the foundation for understanding immune system function.
  • The International HLA Workshops were crucial for analyzing and characterizing this complex genetic system.
  • Early research in Tumour Immunology highlighted the significance of Tumour Associated Transplantation Antigens (TATA).

Purpose of the Study:

  • To provide a historical perspective on the discovery and characterization of the MHC system.
  • To discuss the role of MHC in tumour immunology and T cell recognition of tumour cells.
  • To explore the implications of MHC research for developing new cancer immunotherapies.

Main Methods:

  • Historical review of scientific literature and major discoveries in MHC and tumour immunology.
  • Analysis of the contributions of key scientists and international collaborative efforts like the HLA Workshops.
  • Discussion of experimental findings on tumour cell recognition by T lymphocytes via MHC-presented peptides.

Main Results:

  • MHC molecules present tumour antigenic peptides to T lymphocytes, enabling tumour cell killing.
  • Tumour cells can evade immune recognition by downregulating MHC expression.
  • Decades of research have elucidated the complex interplay between MHC and tumour immunity.

Conclusions:

  • The study of MHC and its role in tumour immunology has significantly advanced our understanding of the immune system's interaction with cancer.
  • The findings have critical implications for the development of next-generation cancer immunotherapies aimed at enhancing T cell responses.
  • Continued research in this field promises further breakthroughs in combating cancer through immune system modulation.