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A new glucoside with a potent α-glucosidase inhibitory activity from Lycium schweinfurthii
Ahmed Elbermawi1,2, Ahmed F Halim1, El-Sayed S Mansour1
1Department of Pharmacognosy Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Abstract:
A new glucoside, 3-methoxy-4-O-β-D-glucopyranosyl-methyl benzoate, has been isolated from Lycium schweinfurthii along with five known compounds through bioactivity guided fractionation of the total plant methanolic extract towards α-glucosidase inhibitory activity. All the isolated compounds were tested for their inhibitory effect on α-glucosidase enzyme. As a result, four of them showed a potent inhibitory activity and thus constitute a therapeutic approach to decrease postprandial hyperglycemia in diabetic patients.
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