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Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
Published on: May 27, 2015
Two new physalin derivatives from Physalis alkekengi L. var. franchetii (Mast.) Makino
Jian-Lu Sun1,2, Yong-Jun Jiang3, Lin Cheng2
1Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin, PR China.
Abstract:
Two new physalin derivatives named 7β-ethoxyl-isophysalin C (1) and 3β-ethoxyl-2,3-dihydro-4,7-didehydrophysalin B (2) were isolated from Physalis alkekengi L. var. franchetii (Mast.) Makino. Their structures were determined by extensive NMR-spectroscopic analysis and HRESIMS data. Compounds 1 and 2 were tested for their cytotoxicity against PC-3 cancer cell lines. Compound 1 showed apparent moderate with IC50 values of 8.26 μM, whereas compound 2 exhibited no cytotoxicity against PC-3 cancer cell lines.
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