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Updated: Jan 24, 2026

Chronic Ovine Model of Right Ventricular Failure and Functional Tricuspid Regurgitation
Published on: March 17, 2023
Unmasking right ventricular dysfunction in chronic rheumatic mitral regurgitation
Ruchika Meel1, Ferande Peters1, Elena Libhaber1
1Division of Cardiology, Chris Hani Baragwanath Academic Hospital and University of the Witwatersrand, Johannesburg, South Africa.
Aims:
Right ventricular (RV) systolic function is an important predictor of mortality but has been poorly studied in chronic rheumatic mitral regurgitation (CRMR). We studied RV systolic function using speckle-tracking echocardiography (STE) in patients with CRMR.
Methods:
Seventy-seven patients with CRMR and 40 healthy controls were enrolled in a cross-sectional study at Chris Hani Baragwanath Hospital between January and October 2014. RV peak systolic strain (PSS) and left ventricular (LV) global longitudinal strain (GLS) were measured using Philips Qlab 9 STE software.
Results:
RVPSS was lower in CRMR patients compared to the controls ( -16.8 ± 4.5 vs -19.2 ± 3.4%, p = 0.003) with no difference in conventional RV systolic function parameters (p = 0.39). RVPSS was lower in severe CRMR compared to moderate CRMR patients ( -14.3 ± 4.23 vs -18 ± 4.18%, p < 0.0001). CRMR patients with LV systolic dysfunction had a greater reduction in RVPSS and LVGLS compared to those with preserved LV systolic function (p = 0.001). LVGLS and significant tricuspid regurgitation (TR) were independent predictors of RVPSS (p < 0.001).
Conclusions:
In CRMR patients, RVPSS was a more sensitive marker for detecting earlier RV systolic dysfunction than traditional RV functional parameters.
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