Related Experiment Video
Updated: Jan 24, 2026
10:52
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
11.6K
Mantle Cell Lymphoma With Mantle Zone Growth Pattern.
Ji Yuan1, Shaoying Li2, Xin Liu3
1Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha.
American Journal of Clinical Pathology
|May 30, 2019
Summary
Mantle cell lymphoma with mantle zone growth pattern (MCL-MZGP) often presents incidentally and resembles reactive lymph nodes. Cyclin D1 staining is crucial for diagnosis, though its clinical significance remains unclear.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Mantle cell lymphoma (MCL) is a rare non-Hodgkin lymphoma.
- MCL with mantle zone growth pattern (MCL-MZGP) presents a diagnostic challenge due to its resemblance to reactive lymphoid hyperplasia.
Purpose of the Study:
- To characterize the clinical and pathologic features of MCL-MZGP.
- To identify diagnostic markers for MCL-MZGP.
Main Methods:
- Analysis of clinicopathologic data from 35 MCL-MZGP cases across 12 centers.
- Immunohistochemical staining for BCL2, CD5, cyclin D1, and SOX11.
Main Results:
- MCL-MZGP cases were often diagnosed at advanced clinical stages (81%) or incidentally found (40%).
- Morphologically, affected lymph nodes showed preserved architecture with expanded mantles containing lymphoma cells.
- Immunohistochemistry revealed positivity for BCL2 (96%), CD5 (82%), cyclin D1 (100%), and SOX11 (89%).
- No significant difference in overall survival was observed between observation and chemotherapy groups.
Conclusions:
- MCL-MZGP is frequently incidentally identified and mimics reactive mantles.
- Cyclin D1 immunostaining is essential for diagnosing suspicious cases.
- The overall clinical significance of MCL-MZGP requires further investigation.
More Related Videos
Related Concept Videos
01:29Oxygen Requirements and Growth Patterns
1.2K
Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
1.2K
02:29Hybrid Zones
21.8K
Hybrid zones are narrow regions where two closely related species interact, mate, and produce hybrids. Relative to either parent species, hybrids may possess distinct phenotypic or genetic differences that impact their survival and reproductive success. The genetic variances introduced by hybridization influence species diversity and speciation processes within the hybrid zone.
21.8K
01:16Zones of Protection
785
In power systems, the entire setup is divided into protective zones to isolate faults and protect the rest of the network. These zones include generators, transformers, buses, transmission lines, distribution lines, and motors. Each zone can be visualized as a separate room in a house, with each room protected by its own circuit breaker.
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
785
01:28Transition Zone
362
The transition zone in concrete is a critical area where aggregate meets cement paste, marked by a distinct porosity and weakness compared to the surrounding material. The adhesion around the aggregates is primarily due to Van Der Waals forces. The voids within this zone influence its robustness; initially, it is less durable than the surrounding bulk mortar due to larger voids. Initially, when concrete is compacted, a higher water-cement ratio near the aggregates leads to the formation of...
362
03:02Primary and Secondary Growth in Roots and Shoots
60.3K
Vascular plants, which account for over 90% of the Earth’s vegetation, all undergo primary growth—which lengthens roots and shoots. Many land plants, notably woody plants, also undergo secondary growth—which thickens roots and shoots.
60.3K
02:36Cells Coordinate Growth and Proliferation
5.0K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
5.0K