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Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
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Characterization of transcriptome profile and clinical features of a novel immunotherapy target CD204 in diffuse

Yongliang Yuan1,2, Qitai Zhao3,4, Songfeng Zhao1,2

  • 1Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Cancer Medicine
|May 30, 2019
PubMed

Insights

CD204, a marker for tumor-associated macrophages in glioma, independently predicts poor patient outcomes and correlates with malignancy. Targeting CD204 may offer a promising avenue for glioma immunotherapy.

Area of Science:

  • Neuro-oncology
  • Immunology
  • Cancer Biomarkers

Background:

  • CD204 is a marker for tumor-associated macrophages (TAMs) in glioma.
  • Its expression and role in glioma progression remain incompletely understood.

Purpose of the Study:

  • To investigate the expression, function, and prognostic significance of CD204 in glioma.
  • To explore CD204's association with molecular subtypes and immune microenvironment.

Main Methods:

  • Analysis of 1323 glioma samples from CGGA and TCGA datasets using microarray and RNA-seq data.
  • Univariate and multivariate Cox regression analyses.
  • Gene Ontology enrichment analysis and correlation studies with immune cell populations and checkpoint regulators.

Main Results:

  • CD204 is an independent prognosticator of poor outcomes in glioma patients.
  • CD204 expression correlates positively with glioma grade and is upregulated in mesenchymal glioblastoma.
  • CD204 is enriched in inflammatory and immune responses, associated with monocytic lineage, fibroblasts, T cells, and immune checkpoint regulators like TIM-3.

Conclusions:

  • CD204 expression reflects glioma malignancy and predicts poor prognosis.
  • CD204+ TAMs may contribute to T-cell dysfunction via immune checkpoints.
  • CD204 presents a potential therapeutic target for enhancing glioma immunotherapy.
Keywords:
CD204biomarkergliomaimmune checkpointsprognosis

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