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The progresses in curcuminoids-based metal complexes: especially in cancer therapy
Yanan Zhang1, Abdur Rauf Khan1, Manfei Fu1
1College of Pharmacy, Department of Pharmaceutics, Shandong University, Jinan 250012, PR China.
Future Medicinal Chemistry
|May 30, 2019
Summary
Metal-based curcuminoid complexes (MBCCs) enhance the properties of curcuminoids (CURs) for cancer treatment. These novel complexes show potential in chemical detection and bio-imaging, overcoming limitations of pure CURs.
Area of Science:
- Medicinal Chemistry
- Materials Science
- Nanotechnology
Background:
- Curcuminoids (CURs) from turmeric (Curcuma longa) show anti-cancer properties.
- CURs face limitations in medical applications due to poor physicochemical properties and side effects.
Purpose of the Study:
- To investigate metal-based complexes with CURs (MBCCs).
- To summarize recent advancements in MBCCs research.
- To evaluate the potential of MBCCs in various applications.
Main Methods:
- Literature review of recent articles on metal-based CURs complexes.
- Analysis of reported improvements in physicochemical properties and therapeutic performance.
- Exploration of novel applications for MBCCs.
Main Results:
- Metal-based CURs complexes (MBCCs) demonstrate improved physicochemical properties compared to pure CURs.
- MBCCs exhibit enhanced therapeutic performances.
- Novel applications in chemical detecting, paramagnetic-luminescent, and bio-imaging are identified.
Conclusions:
- The formation of MBCCs is beneficial for CURs development, particularly in medicine.
- MBCCs offer solutions to the limitations of pure CURs.
- MBCCs hold promise for advanced applications beyond cancer therapy.
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