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Ocular and orbital side effects of ALK inhibitors: a review article

Elias Chelala1, Sandra Hoyek1, Nicolas Arej1

  • 1Saint Joseph University, Faculty of Medicine, Beirut, Lebanon.

Future Oncology (London, England)
|May 30, 2019
PubMed

Insights

Anaplastic lymphoma kinase (ALK) inhibitors, used for non-small-cell lung cancer, can cause ocular toxicity. This review details visual side effects like flashes, blurred vision, and optic neuropathy, aiding understanding of these ALK inhibitor adverse events.

Area of Science:

  • Oncology
  • Ophthalmology
  • Pharmacology

Background:

  • Anaplastic lymphoma kinase (ALK) inhibitors are effective targeted therapies for non-small-cell lung carcinoma.
  • Ocular toxicity is a known adverse effect of these targeted therapies.
  • Limited literature exists on the ophthalmological side effects of ALK inhibitors.

Purpose of the Study:

  • To review and describe the spectrum of ocular side effects associated with ALK inhibitors.
  • To explore potential reasons for variability in reported visual disorders.
  • To consolidate information on visual disturbances caused by ALK inhibitors.

Main Methods:

  • Literature review of studies reporting ophthalmological side effects of ALK inhibitors.
  • Compilation and categorization of reported ocular adverse events.
  • Analysis of potential contributing factors to observed visual disorders.

Main Results:

  • Frequent ocular side effects include photopsia, blurred vision, reduced visual acuity, and accommodation disorders.
  • Other reported effects encompass optic neuropathy, macular edema, diplopia, and cataract.
  • Variability in reported rates of visual disorders may stem from differing methodologies and patient populations.

Conclusions:

  • ALK inhibitors can induce a range of ocular toxicities in non-small-cell lung cancer patients.
  • Awareness of these visual side effects is crucial for timely diagnosis and management.
  • Further research is needed to elucidate the mechanisms and standardize reporting of ALK inhibitor-induced ocular toxicity.
Keywords:
ALK inhibitorsaccommodation disordercataractdiplopiamacular edemaocular side effectsoptic neuropathyorbital side effectsvisual acuityvitreous floaters

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