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A Practical Guide to Phylogenetics for Nonexperts

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Ancillary Tests in Breast Cytology: A Practical Guide.

Francisco Beca¹, Fernando C Schmitt^2,3

¹Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.

Acta Cytologica

|May 30, 2019

Summary

Fine-needle aspiration biopsy (FNAB) of the breast is increasingly used for diagnosing breast lesions and tracking tumor evolution. Combining FNAB with advanced techniques like molecular testing enhances its diagnostic capabilities for various breast cancer applications.

Keywords:

Breast cytopathology Fine-needle aspiration biopsy Immunocytochemistry Molecular cytopathology

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Area of Science:

Oncology
Cytopathology
Molecular Diagnostics

Background:

Fine-needle aspiration biopsy (FNAB) of the breast has evolved significantly over the past decades.
Its utilization for diagnosing breast lesions has seen renewed interest due to its efficiency and minimally invasive nature.

Purpose of the Study:

To review the modern applications of breast FNAB when integrated with contemporary ancillary techniques.
To highlight the clinical utility of FNAB coupled with immunocytochemistry and molecular methods.

Main Methods:

Review of current literature and clinical applications of breast FNAB.
Integration of classic immunocytochemistry (ICC) and advanced molecular techniques, including next-generation sequencing.

Main Results:

Breast FNAB is effective for primary diagnosis, identifying metastatic sources, evaluating prognostic/predictive markers, and tracking tumor evolution.
Ancillary techniques significantly enhance the diagnostic power of FNAB for breast lesions.

Conclusions:

FNAB of the breast, when augmented by modern ancillary techniques, is an ideal sampling method with advantages similar to liquid and tissue biopsies.
This approach offers clinically relevant insights into breast cancer diagnosis and management.