Related Experiment Video
Updated: Jan 24, 2026

Removal of Arsenic Using a Cationic Polymer Gel Impregnated with Iron Hydroxide
Published on: June 28, 2019
Treatment of Arsenic-Induced Bowen’s Disease With Topical 5-Fluorouracil
Abstract:
Here, we present a case of arsenic-induced Bowen’s disease treated with a regimen consisting of topical 5-fluouracil and oral nicotinamide. The use of this therapy modality resulted in near complete resolution of all of the patient’s lesions except for those on her palms, soles, and scalp. Excellent wound care and treatment adherence were major factors contributing to the success of this treatment option. Our results ultimately provide an alternative approach to treating multiple arsenical keratoses in patients who are limited to a drug plan involving 5-FU and oral nicotinamide and who are able to be rigorously compliant with application of medication and wound care. J Drugs Dermatol. 2019;18(5):477-479.
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