Late onset left ventricular dysfunction and cardiomyopathy induced with ibrutinib
Sedanur K Gülsaran1, Mehmet Baysal1, Ufuk Demirci1
1Faculty of Medicine, Department of Hematology, Edirne, Turkey.
Summary
Ibrutinib, used for chronic lymphocytic leukemia, can cause heart failure. This case report highlights the importance of monitoring cardiac function in patients treated with this Bruton
Area of Science:
- Oncology
- Cardiology
- Pharmacology
Background:
- Ibrutinib, a Bruton's tyrosine kinase inhibitor, is a key therapy for chronic lymphocytic leukemia (CLL) and some non-Hodgkin's lymphomas.
- Common adverse effects of ibrutinib include atrial fibrillation, diarrhea, and bleeding, but cardiac failure has not been a widely recognized risk.
Observation:
- A 66-year-old female patient with CLL developed symptomatic left ventricular dysfunction.
- The cardiac dysfunction emerged 13 months after initiating ibrutinib therapy.
Findings:
- Cessation of ibrutinib treatment led to significant improvement in the patient's ejection fraction and clinical symptoms of left ventricular dysfunction.
- This suggests a potential causal link between ibrutinib and the observed cardiac adverse event.
Implications:
- While ibrutinib is generally well-tolerated, this case underscores the need for vigilant cardiac monitoring in patients undergoing treatment.
- Cardiologists and oncologists should consider potential cardiac toxicity, including heart failure, as a possible adverse effect of ibrutinib therapy.
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