Related Experiment Video

Updated: Jan 24, 2026

The Other End of the Leash: An Experimental Test to Analyze How Owners Interact with Their Pet Dogs
08:59

The Other End of the Leash: An Experimental Test to Analyze How Owners Interact with Their Pet Dogs

Published on: October 13, 2017

18.2K

Analgesia during Monkeypox Virus Experimental Challenge Studies in Prairie Dogs (Cynomys ludovicianus)

Christina L Hutson1, Nadia Gallardo-Romero2, Darin S Carroll2

  • 1Centers for Disease Control and Prevention, The University of Georgia, Athens, Georgia; The University of Georgia, Athens, Georgia; Georgia;,

Journal of the American Association for Laboratory Animal Science : JAALAS
|May 31, 2019
PubMed

Insights

Monkeypox virus (MPXV) infection in prairie dogs suggests pain. Meloxicam increased morbidity, while buprenorphine showed minimal impact, informing analgesic use in MPXV studies.

Area of Science:

  • Veterinary Medicine
  • Virology
  • Animal Welfare

Background:

  • Monkeypox virus (MPXV) infection causes pain in humans, suggesting similar experiences in infected animals.
  • Understanding analgesic effects on MPXV disease progression is vital for experimental design and animal welfare.

Purpose of the Study:

  • To investigate the impact of analgesics (meloxicam and buprenorphine) on MPXV disease progression in prairie dogs.
  • To inform decisions regarding analgesic use in MPXV challenge studies.

Main Methods:

  • Prairie dogs were infected with MPXV and treated with meloxicam (NSAID) or buprenorphine (opioid).
  • Control groups received no analgesia or analgesia without MPXV challenge.
  • Animals were serially euthanized to monitor disease progression and viral kinetics.

Main Results:

  • MPXV disease progression and viral kinetics were similar across groups.
  • MPXV-infected animals treated with meloxicam showed increased morbidity and mortality trends.
  • MPXV-infected animals treated with buprenorphine exhibited minimal differences compared to non-analgesia controls.

Conclusions:

  • Meloxicam may negatively impact MPXV disease progression in prairie dogs.
  • Buprenorphine appears to be a safe analgesic option for MPXV-infected animals.
  • Findings support informed analgesic use in MPXV research, enhancing animal welfare and modifying pain assessment scales.

More Related Videos

Culture of Neurospheres Derived from the Neurogenic Niches in Adult Prairie Voles07:34

Culture of Neurospheres Derived from the Neurogenic Niches in Adult Prairie Voles

Published on: June 10, 2020

4.3K
Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats06:32

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Published on: October 24, 2016

27.6K

Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.5K
What are Viruses?00:50

What are Viruses?

Overview
127.9K
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

Body:Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to...
243
Experimental Determination of Chemical Formula02:37

Experimental Determination of Chemical Formula

The elemental makeup of a compound defines its chemical identity, and chemical formulas are the most concise way of representing this elemental makeup. When a compound’s formula is unknown, measuring the mass of its constituent elements is often the first step in determining the formula experimentally.
46.5K
Experimental Designs01:16

Experimental Designs

An experimental design is a systematic process that allows researchers to evaluate the relationship between dependent and independent variables. There are three widely used types of experimental design - pre-experimental design, true experimental design, and quasi-experimental design. In pre-experimental design, the researcher compares the data before and after some interventions or treatments. The true-experimental design has more than one purposefully created group, a commonly measured...
16.7K
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
7.4K