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Updated: Jan 24, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
Published on: June 17, 2025
Ocular Cicatricial Pemphigoid: Camouflaged as Persistent Conjunctivitis
Jamal-Uddin Mughal1, Asif Jan Muhammad2, Uzma Erum2
1Department of Ophthalmology, Patel Hospital, Gulshan-e-Iqbal, Karachi, Pakistan.
Abstract:
Ocular cicatricial pemphigoid (OCP) is a rare autoimmune disease with heterogenous clinical manifestations. The classical lesion involves ocular conjunctiva that leads to progressive scarring and fibrosis which ultimately results in visual loss. We report a case of a young male, who had chronic conjunctivitis which remained un-responsive to conventional treatment and results in significant morbidity. Later, it was diagnosed as ocular cicatricial pemphigoid involving eyes, nasal cavity, larynx as well as skin. Patient received immuo-suppressive therapy, which helped in arresting the disease process.
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