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Updated: Jan 24, 2026
05:05
Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
Published on: June 17, 2025
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Ocular Cicatricial Pemphigoid: Camouflaged as Persistent Conjunctivitis.
Jamal-Uddin Mughal1, Asif Jan Muhammad2, Uzma Erum2
1Department of Ophthalmology, Patel Hospital, Gulshan-e-Iqbal, Karachi, Pakistan.
Summary
Ocular cicatricial pemphigoid (OCP) is a rare autoimmune disease causing scarring and vision loss. This case highlights OCP affecting multiple sites, successfully managed with immunosuppressive therapy.
Area of Science:
- Ophthalmology
- Autoimmune Diseases
- Dermatology
Background:
- Ocular cicatricial pemphigoid (OCP) is a rare, chronic autoimmune blistering disease.
- It primarily affects mucous membranes, especially the conjunctiva, leading to scarring and vision loss.
Observation:
- A young male presented with chronic, treatment-resistant conjunctivitis.
- The condition progressed to involve the nasal cavity, larynx, and skin, indicating widespread OCP.
Findings:
- The patient was diagnosed with ocular cicatricial pemphigoid based on multi-site involvement.
- Immunosuppressive therapy was initiated to manage the autoimmune process.
Implications:
- This case underscores the importance of considering OCP in refractory conjunctivitis with potential systemic involvement.
- Early diagnosis and prompt immunosuppressive treatment are crucial for halting disease progression and preserving function.
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