Related Experiment Video
Updated: Jan 24, 2026

Studying Aggression in Drosophila fruit flies
Published on: February 25, 2007
Novel HMGA2-YAP1 fusion gene in aggressive angiomyxoma
Mee-Young Lee1, Brandon da Silva2, Daniel C Ramirez3,4
1Cancer Institute, Northwell Health, Lake Success, New York, USA.
Abstract:
We describe a case of a 44-year-old woman with locally advanced aggressive angiomyxoma with a novel translocation high-mobility group AT-hook 2-yes-associated protein 1 (HMGA2-YAP1) fusion, implying a t(11;12)(q22.1;q14.3) translocation. She was started on gonadotropin-releasing hormone agonist injection and an aromatase inhibitor for persistent disease, which responded to treatment; she was subsequently treated with radiation before a more definitive operation was conducted. This case report indicates that HGMA2-YAP1-translocated aggressive angiomyxoma is responsive to oestrogen antagonism and hopefully will allow for the development of diagnostics useful for this rare but often morbid neoplasm. This case also highlights the importance of appropriate workup of a soft tissue mass.
Related Concept Videos
Aggression
Nuclear Fusion
A helium nucleus has a mass that is 0.7% less than that of four hydrogen nuclei; this lost mass is converted into energy during the fusion. This reaction produces about...
Secondary Motives: Affiliation Motivation and Aggression Motivation
Tagging and Fusion Proteins
SNAREs and Membrane Fusion
SNAREs exist in pairs that symmetrically interact and catalyze the fusion of the lipid bilayers in vesicle and target organelle. v-SNARE in the vesicle membrane are single polypeptide chains that bind to a complementary t-SNARE, composed of 2...
Gene Flow

