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Related Experiment Videos

Abnormal intestinal permeability and jejunal morphometry.

L D Juby, M F Dixon, A T Axon

    Journal of Clinical Pathology
    |July 1, 1987
    PubMed
    Summary
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    Computed jejunal morphometry detects subtle intestinal permeability changes. This advanced technique identifies abnormalities even when routine microscopy appears normal, aiding in coeliac disease diagnosis.

    Area of Science:

    • Gastroenterology
    • Intestinal Physiology
    • Diagnostic Imaging

    Background:

    • The cellobiose and mannitol differential sugar test assesses small bowel permeability.
    • Abnormal permeability is linked to coeliac disease, but routine jejunal microscopy may appear normal.
    • Subtle morphological changes may underlie abnormal intestinal permeability.

    Purpose of the Study:

    • To compare computed jejunal morphometry with the cellobiose:mannitol ratio in patients with varying degrees of intestinal permeability and jejunal morphology.
    • To determine if computed morphometry can identify subtle mucosal changes associated with abnormal intestinal permeability.

    Main Methods:

    • A prospective study involving three patient groups: coeliac disease with villous atrophy, normal jejunums/sugar tests, and normal jejunums/abnormal sugar tests.

    Related Experiment Videos

  • Measurement of the perimeter:lamina propria area index in jejunal biopsy samples using computed morphometry.
  • Comparison of the morphometric index with the cellobiose:mannitol permeability index.

    • Main Results:

    • A significant difference in the perimeter:lamina propria area index was found between coeliac patients and those with normal findings (p < 0.001).
    • Patients with normal jejunums but abnormal sugar test results also showed an abnormal index (p < 0.001 vs. coeliac; 0.01 > p > 0.001 vs. normal).
    • A significant overall correlation (p = 0.001) was observed between the perimeter:lamina propria area index and the cellobiose:mannitol ratio.

    Conclusions:

    • Computed jejunal morphometry can identify subtle morphological changes related to abnormal intestinal permeability.
    • This technique offers a valuable tool for diagnosing conditions with impaired small bowel permeability, even when standard histology is unremarkable.
    • Morphometry enhances the diagnostic capability beyond routine microscopy for assessing intestinal barrier function.