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Updated: Jan 24, 2026
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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
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Altered functional connectivity density in primary angle-closure glaucoma patients at resting-state
Linglong Chen1, Shenghong Li1, Fengqin Cai1
1Department of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang 330006, China.
Quantitative Imaging in Medicine and Surgery
|May 31, 2019
Summary
Primary angle-closure glaucoma (PACG) causes widespread brain dysfunction, altering functional connectivity density (FCD) in specific brain regions. These changes correlate with disease severity, indicating PACG
Area of Science:
- Neuroscience
- Ophthalmology
- Medical Imaging
Background:
- Primary angle-closure glaucoma (PACG) is a neurodegenerative disease affecting the brain.
- Previous functional magnetic resonance imaging (fMRI) studies indicate widespread spontaneous brain activity dysfunction in PACG.
- This study investigates altered cortical functional connectivity (FC) in PACG using a graph theory approach.
Purpose of the Study:
- To investigate altered local and global functional connectivity (FC) of the cortex in primary angle-closure glaucoma (PACG) patients.
- To apply a data-driven functional connectivity density (FCD) mapping approach.
- To explore correlations between brain connectivity alterations and clinical variables in PACG.
Main Methods:
- Resting-state fMRI scans were acquired from 45 PACG patients and 46 healthy controls (HCs).
- Functional connectivity density (FCD) differences for short-range and long-range connections were calculated between groups.
- Correlations between FCD values in altered regions and clinical measures (RNFLT, IOP, A-C/D) were analyzed.
Main Results:
- PACG patients exhibited increased short-range FCD in the left and right inferior frontal gyrus (IFG)/insula and parahippocampal gyrus.
- Decreased short-range FCD was observed in the occipital, cuneus, precuneus, superior parietal, and postcentral lobes in PACG patients.
- Reduced long-range FCD was found in the left middle frontal gyrus of PACG patients compared to HCs.
- Retinal nerve fiber layer thickness (RNFLT) positively correlated with decreased short-range FCD in posterior brain regions.
- Average cup to disc ratio (A-C/D) negatively correlated with increased short-range FCD in the frontal and insular regions.
Conclusions:
- Primary angle-closure glaucoma (PACG) is associated with extensive brain dysfunction.
- PACG induces distinct spatial alterations in both short-range and long-range functional connectivity.
- Brain connectivity changes in PACG are linked to specific clinical ophthalmological parameters.
Keywords:
Primary angle-closure glaucoma (PACG)functional connectivity (FC)functional connectivity density mapping (FCD mapping)resting-state functional magnetic resonance imaging (fMRI)visual pathwayMore Related Videos
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