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Updated: Jan 24, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices
Published on: March 21, 2025
Device exchange from HeartMate II to HeartMate 3 left ventricular assist device
Koji Takeda1, Hiroo Takayama1, Joseph Sanchez1
1Department of Surgery, Division of Cardiothoracic Surgery, Columbia University Medical Center, New York, NY, USA.
Insights
Exchanging the HeartMate II (HMII) left ventricular assist device to the HeartMate 3 (HM3) is feasible. However, risks include pump pocket infection and inflow malposition, necessitating careful patient selection and monitoring.
Area of Science:
- Cardiology
- Cardiovascular Surgery
- Medical Device Technology
Background:
- The HeartMate II (HMII) left ventricular assist device (LVAD) is often exchanged for the HeartMate 3 (HM3) to mitigate risks like device thrombosis and stroke.
- Data on the outcomes of HMII to HM3 exchange procedures are limited, highlighting the need for further clinical investigation.
Observation:
- This study reviewed early and mid-term outcomes of 9 patients undergoing HMII to HM3 exchange.
- Indications for exchange included device thrombosis (8.89%) and driveline injury (1.11%).
- Procedures were performed via lateral thoracotomy, with a median cardiopulmonary bypass time of 117 minutes.
Findings:
- In-hospital mortality was 0%. One patient required pump repositioning due to inflow malposition.
- During a median follow-up of 486 days, 33% of patients developed late HMII pump pocket infection.
- Five patients successfully received a heart transplant; one patient died from an unknown cause.
Implications:
- HMII to HM3 exchange is achievable through lateral thoracotomy, offering a potential surgical approach.
- Potential complications such as inflow malposition and infection of the previous pump pocket require careful consideration and management strategies.
- Further research is warranted to optimize surgical techniques and patient management for LVAD exchange procedures.
Abstract:
The HeartMate II (HMII) left ventricular assist device can be exchanged to HeartMate 3 (HM3) to reduce the risk of device thrombosis and stroke. However, data of this procedure are still limited. We reviewed early and mid-term outcomes of 9 patients who received a HMII to HM3 exchange at our institution. The median age of the cohort was 58 years [interquartile range (IQR) 53-61], and 7 (78%) patients were men. The median duration of HMII support was 608 days (IQR 493-1116). Indications for device exchange include device thrombosis (n = 8.89%) and driveline injury (n = 1.11%). Procedures were performed through a lateral thoracotomy in all patients. The median cardiopulmonary bypass time was 117 min (IQR 97-133). In-hospital mortality was 0%. One patient required repositioning of the HM3 pump through full sternotomy due to inflow malposition. During 486 days (IQR 235-712) of follow-up, 3 patients (33%) developed late HMII pump pocket infection after discharge. Five patients had a successful heart transplant and 1 patient died due to unknown reason. HMII to HM3 exchange can be performed via lateral thoracotomy. However, there is a risk of inflow malposition and previous pump pocket infection.
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