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Updated: Jan 24, 2026

Construction and Characterization of a Novel Vocal Fold Bioreactor
Published on: August 1, 2014
Vocal fold scars: a common classification proposal by the American Laryngological Association and European
Anastasios Hantzakos1,2, Frederik G Dikkers3, Antoine Giovanni4
1Department of Otolaryngology Head and Neck Surgery, Surgical Subspecialties Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, 112412, UAE. HantzaA@ClevelandClinicAbuDhabi.ae.
Purpose:
Vocal fold scar is one the most challenging benign laryngeal pathologies. The purpose of this paper is to propose a classification that will allow for a common description of this entity between laryngologists, prevent discrepancies in interpretation, allow for comparison of related studies, and offer a training tool for young laryngologists.
Methods/Results:
Based on the depth and laterality of scarring, we propose 4 types: type I, characterized by atrophy of lamina propria with/without affected epithelium; type II, where the epithelium, lamina propria, and muscle are affected; type III, where the scar is located on the anterior commissure; type IV, which includes extended scar formation in both anteroposterior and rostro-caudal axis with significant loss of vocal fold mass.
Conclusion:
We believe that our proposal is comprehensive and encompasses all existing iatrogenic and non-iatrogenic etiologies in a simple and concise manner. It also serves its purpose as a descriptive, comparative, and training tool.
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