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Super-resolution Imaging of Proteus mirabilis Biofilm by Expansion Microscopy
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Virulence targeted inhibitory effect of linalool against the exclusive uropathogen Proteus mirabilis

Ravindran Durgadevi1, Arumugam Veera Ravi1, Rajaiah Alexpandi1

  • 1Department of Biotechnology, Alagappa University , Tamil Nadu , India.

Biofouling
|May 31, 2019
PubMed

Insights

Linalool, a natural compound, effectively reduces biofilm formation and virulence in Proteus mirabilis, a common cause of catheter-associated urinary tract infections (CAUTI). This suggests linalool

Area of Science:

  • Microbiology
  • Natural Product Chemistry
  • Urology

Background:

  • Proteus mirabilis is a primary cause of catheter-associated urinary tract infections (CAUTI).
  • Biofilm formation by P. mirabilis contributes to antibiotic resistance, complicating treatment.
  • Virulence factors, such as urease, promote P. mirabilis biofilm development and urinary tract issues.

Purpose of the Study:

  • To investigate the anti-biofilm and anti-virulence potential of linalool against P. mirabilis.
  • To determine the effect of linalool on urease production and biofilm-associated genes in P. mirabilis.

Main Methods:

  • In vitro assessment of linalool's anti-biofilm activity against P. mirabilis.
  • Quantification of urease activity in P. mirabilis treated with varying concentrations of linalool.
  • Quantitative PCR (q-PCR) analysis to evaluate the expression of biofilm and virulence genes.

Main Results:

  • Linalool demonstrated concentration-dependent inhibition of P. mirabilis biofilm formation.
  • Treatment with linalool led to reduced urease production, impacting urinary pH and crystal formation.
  • q-PCR results confirmed the down-regulation of key biofilm and virulence genes following linalool exposure.

Conclusions:

  • Linalool exhibits significant anti-biofilm properties against P. mirabilis.
  • Linalool effectively attenuates virulence factors, including urease production.
  • Linalool presents a promising natural agent for combating P. mirabilis-associated CAUTI.
Keywords:
Antibiofilm activityantivirulence activitycrystalline biofilmlinaloolmotilityproteus

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