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Measuring Protein Stability in Living Zebrafish Embryos Using Fluorescence Decay After Photoconversion FDAP
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Electronic Decay Length in a Protein Molecule.

Bintian Zhang, Stuart Lindsay

    Nano Letters
    |May 31, 2019
    PubMed
    Summary

    Antibody electrical conductivity was measured using two distinct methods. One method showed stable conductance regardless of electrode gap size, while the other revealed a long electronic decay length, suggesting unique charge transport properties.

    Area of Science:

    • Molecular electronics
    • Biophysics
    • Immunology

    Background:

    • Antibodies possess unique bivalent binding sites.
    • Understanding charge transport through biomolecules is crucial for molecular electronics.

    Purpose of the Study:

    • To investigate the electrical conductivity of antibodies.
    • To characterize charge transport mechanisms across antibody molecules.

    Main Methods:

    • Fabrication of electrode pairs functionalized with antibody epitopes.
    • Measurement of electrical conductance across antibody bridges under varying electrode gap sizes.
    • Analysis of distance-dependent conductance to determine electronic decay length.

    Main Results:

    • Antibodies formed a stable conducting bridge between two electrodes, with conductance independent of electrode gap size.
    Keywords:
    Molecular electronicsbioelectronicselectronic decay lengthprotein conductance

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  • A second conduction pathway, involving one specific and one nonspecific attachment, exhibited conductance that varied with gap size.
  • An electronic decay length greater than 6 nm was estimated, exceeding that of typical organic molecular wires.

    • Conclusions:

    • Antibodies can function as molecular wires with distinct conduction mechanisms.
    • The long decay length suggests efficient charge transport through antibodies, with potential applications in biosensing and molecular electronics.