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Anesthesia and brain tumor surgery: technical considerations based on current research evidence
Junichi Saito1,2, Joe Masters2, Kazuyoshi Hirota1
1Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Current Opinion in Anaesthesiology
|May 31, 2019
Summary
Anesthetics may impact cancer recurrence after surgery. Current evidence is insufficient to determine the optimal anesthetic technique for brain tumor surgery, necessitating further research.
Area of Science:
- Neuroscience
- Oncology
- Anesthesiology
Background:
- Anesthetics may influence cancer recurrence and metastasis through neuroendocrine stress response or direct effects on cancer cells.
- Mortality rates after cancer surgery, including brain tumor resection, remain high despite technological advancements.
Purpose of the Study:
- To review current evidence on the effects of commonly used anesthetics on postoperative outcomes in solid organ cancer surgery.
- To specifically focus on the impact of anesthetics on neurological malignancies and brain tumor outcomes.
Main Methods:
- Literature review of preclinical and clinical studies.
- Analysis of evidence regarding anesthetic effects on cancer cell biology and tumor progression.
Main Results:
- Preclinical studies suggest anesthetics can affect brain tumor cell biology, progression, and metastasis.
- Clinical evidence is currently inadequate to establish definitive conclusions on optimal anesthetic techniques for brain tumor surgery.
Conclusions:
- Further basic science and clinical research is crucial.
- Investigating the association between perioperative factors, anesthetics, and postoperative brain tumor outcomes is urgently needed.
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