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Updated: Jan 24, 2026

Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT
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Added predictive value of 18F-FDG PET/CT for pediatric rhabdomyosarcoma

Esraa El-Kholy1,2, Enas El Nadi3,4, Hanafy Hafez4

  • 1Nuclear Medicine and Radiation Oncology Department, National Cancer Institute (NCI), Cairo University.

Nuclear Medicine Communications
|May 31, 2019
PubMed

Insights

Higher fluorine-18-fluorodeoxyglucose (F-FDG) standardized uptake value (SUV) in pediatric rhabdomyosarcoma (RMS) indicates a worse prognosis. This finding suggests F-FDG PET/CT can aid in predicting outcomes for RMS patients.

Area of Science:

  • Nuclear Medicine
  • Pediatric Oncology
  • Radiology

Background:

  • Pediatric rhabdomyosarcoma (RMS) is a significant childhood cancer.
  • Accurate prognostic markers are crucial for tailoring treatment strategies in pediatric RMS.
  • Fluorine-18-fluorodeoxyglucose (F-FDG) Positron Emission Tomography/Computed Tomography (PET/CT) is increasingly used in oncology.

Purpose of the Study:

  • To evaluate the prognostic significance of quantitative F-FDG standardized uptake value (SUV) in pediatric RMS patients.
  • To determine if SUVmax and primary/liver SUVmax ratio can predict event-free survival (EFS) and overall survival (OS).

Main Methods:

  • Retrospective analysis of 98 pediatric RMS patients who underwent initial staging PET/CT.
  • Assessment of primary SUVmax and primary/liver SUVmax ratio as predictors of 36-month EFS and OS.
  • Utilized receiver operating characteristic (ROC) curve analysis, univariate, and multivariate analyses.

Main Results:

  • Higher SUVmax correlated with regional/distant metastasis and poorer prognosis.
  • Cut-off values for primary SUVmax (3.6) and primary/liver SUVmax ratio (2.1) were identified.
  • Lower SUVmax values were associated with improved EFS and OS, though statistical significance varied.
  • High SUVmax was linked to unfavorable clinical and pathological features.

Conclusions:

  • F-FDG PET/CT quantitative parameters, specifically SUVmax, show prognostic value in pediatric RMS.
  • Elevated F-FDG uptake suggests a worse outcome and correlates with adverse prognostic factors.
  • F-FDG PET/CT can serve as an additional tool for predicting outcomes in RMS patients.
Abstract

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