Related Experiment Video
Updated: Jan 24, 2026
Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
Published on: May 19, 2015
Depression may not be a risk factor for mortality in stroke patients with nonsurgical treatment: A retrospective
Hsing-Jung Li1, Chao-Chan Kuo2, Ying-Chun Li3
1Department of Child & Adolescent Psychiatry.
Insights
Depression does not increase mortality risk in stroke patients receiving non-surgical treatment. Hemorrhagic stroke, age, sex, and comorbidity scores were identified as significant risk factors for death in this patient group.
Area of Science:
- Neurology
- Psychiatry
- Public Health
Background:
- Patients with depression exhibit higher comorbidity rates and face increased risks of stroke with poorer prognoses.
- Existing research on depression and stroke prognosis often overlooks surgical interventions and other critical risk factors.
- The financial burden of depression-associated comorbidities significantly contributes to overall depression treatment costs.
Purpose of the Study:
- To investigate whether depression is an independent risk factor for mortality in stroke patients undergoing non-surgical treatment.
- To adjust for potential confounding variables, including comorbidities and socioeconomic factors, in the analysis of depression and stroke outcomes.
Main Methods:
- Retrospective analysis of patients diagnosed with major depressive disorder (MDD) and age/sex-matched controls without MDD from 1999-2005.
- Identification of stroke incidence in both groups, followed by analysis of mortality risk factors in non-surgically treated stroke patients during 2006-2012.
- Statistical adjustment for various risk factors, including Charlson Comorbidity Index Scores (CCISs), socioeconomic status (SES), and specific comorbidities.
Main Results:
- Patients with MDD presented with higher CCISs and more frequent comorbidities (diabetes, hypertension, hyperlipidemia, coronary heart disease) compared to controls.
- Stroke patients with MDD on non-surgical treatment were predominantly female, had varied SES, and higher CCISs and comorbidity frequencies than non-MDD stroke patients.
- Depression was not found to be a significant risk factor for mortality in stroke patients receiving non-surgical treatment.
Conclusions:
- Hemorrhagic stroke, advanced age, sex, and higher CCISs are significant predictors of mortality in non-surgically treated stroke patients.
- Depression status does not appear to influence the mortality rate among stroke patients who do not undergo surgical treatment.
- Further research may be warranted to explore the complex interplay between depression, stroke, and treatment modalities on patient outcomes.
Abstract:
Patients with depression have more comorbidities than those without depression. The cost of depression-associated comorbidities accounts for the largest portion of the growing cost of depression treatment. Patients with depression have a higher risk of stroke with poor prognoses than those without depression; however, previous studies evaluating the relationship between depression and stroke prognosis have not accounted for surgical treatment or other risk factors. Therefore, we investigated whether depression is a risk factor for mortality in stroke patients with nonsurgical treatment after adjusting for other risk factors.We retrospectively analyzed the data of patients with major depressive disorder (MDD) and age and sex-matched controls without MDD during 1999 to 2005. We then identified patients who developed stroke in both groups and analyzed risk factors for death in these stroke patients who received nonsurgical treatments during a follow-up period from 2006 to 2012.Patients with MDD had higher Charlson Comorbidity Index Scores (CCISs) and exhibited higher frequencies of comorbidities such as diabetes mellitus, hypertension, hyperlipidemia, and coronary heart disease than controls without MDD, and most of MDD patients had very low or high socioeconomic status (SES) and lived in urban settings. Most stroke patients with MDD who received nonsurgical treatment were female, had very low or high SES, and lived in urban settings; in addition, stroke patients with MDD who received nonsurgical treatment had higher CCISs and frequencies of hyperlipidemia and coronary heart disease than those without MDD who received nonsurgical treatment. However, depression was not a risk factor for death in stroke patients with nonsurgical treatment.Hemorrhagic stroke, age, sex, and CCISs were risk factors for death in stroke patients with nonsurgical treatment, but depression did not affect the mortality rate in these patients.
Related Concept Videos
01:26Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
01:29Factors Affecting Protein-Drug Binding: Patient-Related Factors
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
01:05Long-term Depression
01:03Long-term Depression
Calcium Ion Concentration Mechanism
If over...
03:12Freezing Point Depression and Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
01:28Depressants
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...