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Updated: Jan 24, 2026
09:41
An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
9.1K
Response to pneumococcal vaccination in multiple myeloma
Loïc Renaud1, Susanna Schraen2, Guillemette Fouquet1
1Department of Hematology, CHU Lille, Lille, France.
Cancer Medicine
|May 31, 2019
Summary
Multiple myeloma patients show a positive response to pneumococcal vaccines, with antibody levels decreasing over time and after transplantation. Further research is needed to optimize vaccination strategies for these immunocompromised individuals.
Area of Science:
- Immunology
- Oncology
- Vaccinology
Background:
- Streptococcus pneumoniae infections pose significant risks for multiple myeloma patients.
- Pneumococcal vaccination is recommended for immunocompromised individuals, but response data in multiple myeloma is limited.
Purpose of the Study:
- To evaluate the longitudinal immune response to pneumococcal vaccination in multiple myeloma patients.
- To assess the impact of treatment, including autologous stem cell transplantation (ASCT), on vaccine response.
Main Methods:
- Twenty-eight multiple myeloma patients received Prevnar13® and Pneumo23® vaccines.
- Serotype-specific IgG antibodies were measured longitudinally using ELISA.
- Primary endpoint: incidence of patients achieving an isotype response; secondary endpoints: antibody increase, time to response, and infection rates.
Main Results:
- 85% of patients responded to at least one antibody subtype post-vaccination.
- Antibody concentrations increased threefold, with optimal response when Pneumo23® followed Prevnar13® by over 30 days.
- Antibody levels significantly decreased over time and after ASCT.
Conclusions:
- Multiple myeloma patients can mount an immune response to pneumococcal vaccines, irrespective of hypogammaglobulinemia or treatment.
- A decline in serum antibody response is observed over time and post-transplantation.
- Further studies are required to determine optimal vaccination strategies for this population.
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