Allogeneic heart-lung transplantation in mice

Using a simpler technique for mouse heart and lung transplantation, a histological comparison was made between groups of syngeneic and allogeneic transplants. The initial high postoperative mortality encountered was due to technical difficulty and as the operative technique improved, mortality lessened. While direct palpation of the abdomen is the key means in the detection of graft rejection, there is no practical determination of such graft rejection other than histological clarification. Doppler tracing also is not a sensitive method for detecting rejection. The transplantation technique in this study compares the time of rejection of heart and lung transplants more legitimately.