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Morphological and histopathological evaluation of autopsied patients with hypertensive cardiopathy

Guilherme Ribeiro Juliano1, Laura Sanches Aguiar1, Maria Luíza Gonçalves Dos Reis Monteiro1

  • 1General Pathology Department, Biological and Natural Sciences Institute (ICBN), Federal University of Triângulo Mineiro (UFTM), Av. Frei Paulino, 30, 38025-180, Uberaba, MG, Brazil.

Annals of Diagnostic Pathology
|May 31, 2019
PubMed

Insights

Mast cells play a key role in hypertensive heart disease (HD). Increased mast cell density in the heart and coronary arteries contributes to collagen remodeling in this condition.

Area of Science:

  • Cardiovascular Pathology
  • Immunohistochemistry
  • Morphometry

Background:

  • Hypertensive heart disease involves complex interactions within the myocardium.
  • Understanding these interactions is crucial for clarifying determinant factors.

Purpose of the Study:

  • To analyze morphological changes in hypertensive cardiopathy.
  • To compare findings and elucidate contributing factors.

Main Methods:

  • Analysis of left ventricular myocardium and coronary artery samples from 42 autopsied individuals.
  • Groups: Hypertensive Heart Disease (HD) vs. No Disease (ND).
  • Measurements included wall thickness, collagen fiber quantification, and mast cell density via immunohistochemistry.

Main Results:

  • Significant increases in heart weight, left ventricular wall thickness, and collagen fibers in the HD group.
  • Elevated mast cell density observed in the left ventricle and coronary arteries of individuals with HD.

Conclusions:

  • Mast cells are implicated in the pathogenesis of hypertensive heart disease.
  • Mast cell involvement contributes to collagen fiber remodeling in this condition.
Abstract

Keywords:
AutopsyHypertensive Heart DiseaseMast Cells

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