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Updated: Jan 24, 2026

Culture and Maintenance of Human Embryonic Stem Cells
Published on: December 22, 2009
Development, ontogeny, and maintenance of TCRαβ+ CD8αα IEL
Roland Ruscher1, Kristin A Hogquist1
1Center for Immunology and Department of Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, MN, USA.
Abstract:
The intestinal epithelium is the outermost cellular layer that separates the body from the gut lumen. The integrity of this protective mucosal barrier is crucial and maintained by specialized cells-intraepithelial lymphocytes (IEL). Much research has been conducted on these cells and our overall understanding of them is increasing rapidly. In this review we focus on the TCRαβ+ subset of CD8αα IEL. We discuss recent studies that shed light on the development, ontogeny, maintenance, and functional characteristics of CD8αα IEL, and highlight yet unanswered questions for future studies.
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