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It is essential to understand the difference between chiral and achiral interactions and the implications thereof in optical activity and their applications. Just as our feet, which are chiral, interact uniquely with chiral objects, such as a pair of shoes, but identically with achiral socks, enantiomers of a molecule exhibit different properties only when they interact with other chiral media. An example of a significant implication from this facet is the phenomenon known as optical activity,...
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Updated: Jan 24, 2026

Preparation and Characterization of Graphene-Based 3D Biohybrid Hydrogel Bioink for Peripheral Neuroengineering
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3D optical detection in radiodosimetry: EasyDosit hydrogel characterization.

Jérémy Coulaud1, Véronique Brumas1, Patrick Sharrock1

  • 1SIMAD LU 50, Université Toulouse 3 Paul Sabatier, avenue Georges Pompidou, 81004 Castres, France.

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
|May 31, 2019
PubMed
Summary

Gelatin-based hydrogels show promise as 3D-dosimeters for optical computed tomography (OCT). Their stable optical properties and controlled dye diffusion enable precise radiation detection in tissue phantoms.

Keywords:
DosimetryDyesGelatinHydrogelPhantomSucrose

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Area of Science:

  • Biomedical Engineering
  • Optical Physics
  • Materials Science

Background:

  • Developing accurate 3D dosimeters is crucial for radiation therapy.
  • Optical Computed Tomography (OCT) offers non-invasive imaging capabilities.
  • Tissue phantoms are needed to simulate radiation interaction with biological tissues.

Purpose of the Study:

  • To investigate gelatin-based hydrogels as potential 3D dosimeters.
  • To evaluate their spectrophotometric behavior with and without dyes.
  • To formulate stable tissue phantoms for OCT applications.

Main Methods:

  • Spectrophotometric analysis of hydrogels with and without dyes (Bromophenol Blue, Bromocresol Green, Xylenol Orange).
  • Determination of dye diffusion coefficients as a function of hydrogel composition.
  • Assessment of hydrogel transparency, optical density stability, and dye concentration response.

Main Results:

  • Gelatin-based hydrogels exhibit good transparency and stable baseline optical density.
  • Hydrogels showed a higher optical density response to dyes compared to aqueous solutions.
  • The inclusion of sucrose as a thickener significantly reduced dye mobility (e.g., halved Bromophenol Blue mobility).

Conclusions:

  • Gelatin-based hydrogels possess suitable optical properties for 3D dosimetry.
  • Controlled dye diffusion within these hydrogels allows for stable phantom formulation.
  • These hydrogels are viable for optical detection-based 3D dosimetry in OCT systems.