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Differential intrinsic functional connectivity changes in semantic variant primary progressive aphasia.

Giovanni Battistella1, Maya Henry2, Benno Gesierich1

  • 1Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.

Neuroimage. Clinical
|June 1, 2019
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Summary

Semantic variant primary progressive aphasia (svPPA) involves semantic memory loss. This study reveals altered functional connectivity in svPPA patients, impacting semantic networks and potentially showing adaptive brain changes.

Keywords:
Functional connectivityLanguageParietal lobePrimary progressive aphasiaResting-state connectivity

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Area of Science:

  • Neuroscience
  • Cognitive Neurology
  • Neuroimaging

Background:

  • Semantic variant primary progressive aphasia (svPPA) is defined by semantic memory deficits with preserved speech production.
  • Anterior temporal lobe (ATL) neurodegeneration is linked to svPPA's semantic impairments.
  • Large-scale functional connectivity alterations in svPPA remain less understood, especially concerning language network interplay.

Purpose of the Study:

  • To investigate functional connectivity changes in svPPA using resting-state fMRI.
  • To examine connectivity of semantic, articulatory-phonological, and visual-linguistic networks.
  • To correlate connectivity patterns with specific cognitive deficits in svPPA.

Main Methods:

  • Whole-brain, seed-based connectivity analysis on task-free MRI data from 16 svPPA patients and 32 healthy controls.
  • Seeds were placed in the anterior temporal lobe (ATL), opercular inferior frontal gyrus, and posterior inferior temporal lobe.
  • Comparison of functional connectivity strength across three identified networks between patients and controls.

Main Results:

  • svPPA patients showed decreased functional connectivity in the ventral semantic network, correlating with semantic deficits.
  • Connectivity in the posterior inferior temporal lobe network correlated with pseudoword reading skills.
  • Increased connectivity between the inferior frontal gyrus and angular gyrus suggested potential adaptive responses in svPPA.

Conclusions:

  • Findings support a functional subdivision of the left inferior parietal lobule (IPL) based on its connectivity.
  • svPPA offers a model for understanding the functional interplay and regulation of language networks in neurodegenerative disease.
  • Altered connectivity patterns highlight the complex neural underpinnings of svPPA's unique cognitive profile.