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Current Understanding of Human Enterovirus D68
Jing Sun1, Xiao-Yi Hu2, Xiao-Fang Yu3
1Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang, China. 21718306@zju.edu.cn.
Viruses
|June 1, 2019
Summary
Human enterovirus D68 (EV-D68) causes severe respiratory illness and acute flaccid myelitis (AFM) in children. This review explores EV-D68
Area of Science:
- Virology
- Infectious Diseases
- Public Health
Background:
- Human enterovirus D68 (EV-D68) was first isolated in 1962 but increased globally after a 2014 outbreak.
- EV-D68 infection causes severe respiratory illness and is linked to acute flaccid myelitis (AFM) in children.
- Current treatment for EV-D68 is limited to supportive care, with no specific antiviral drugs or vaccines available.
Purpose of the Study:
- To provide an overview of current research on EV-D68.
- To explore EV-D68 genotypes, genetic characteristics, and infection mechanisms.
- To deepen understanding of EV-D68's biological features and its link to AFM for antiviral development.
Main Methods:
- Review of current scientific literature on EV-D68.
- Analysis of epidemiological data and genetic characteristics of recent EV-D68 strains.
- Exploration of EV-D68 pathogenesis and virus-host interactions.
Main Results:
- EV-D68 exhibits diverse genotypes and genetic characteristics in recent epidemics.
- The virus employs specific mechanisms for infection and interacts with host cells.
- A strong association exists between EV-D68 and the development of acute flaccid myelitis (AFM).
Conclusions:
- Further research into EV-D68's virology and pathogenesis is crucial.
- Understanding virus-host interactions can guide the development of targeted antiviral therapies.
- This review provides a foundation for developing effective treatments and vaccines against EV-D68.
Keywords:
Enterovirus D68 (EV-D68)acute flaccid myelitis (AFM)genomic characteristicsimmune antagonisminfection mechanismMore Related Videos
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