Related Experiment Video
Updated: Jan 24, 2026

Chronic Social Defeat Stress in Early Adolescent Male Mice
Published on: January 24, 2025
The role of dissociation and abuse among adolescents who self-harm
Carlos Hoyos1, Vincent Mancini2,3, Yulia Furlong4
1Child and Adolescent Psychiatry, Solent NHS Trust, Southampton, UK.
Objectives:
Retrospective recall of dissociative symptoms has been found to mediate the association between childhood abuse and deliberate self-harm (DSH) in later life. To disentangle the effect of recall bias, we tested whether dissociation symptoms ascertained during an acute DSH presentation mediates this link.
Method:
All participants with DSH were recruited during emergency presentation. Seventy-one individuals aged 11-17 years with overdose (OD) and/or self-injury (SI) participated in semi-structured interviews and psychiatric assessment to measure abuse and dissociation. An age- and gender-matched comparison group of 42 non-psychiatric patients admitted to the same service were also assessed.
Results:
The DSH groups reported significantly higher levels of abuse and dissociation compared to comparison group. Dissociation significantly mediated the association between abuse and DSH. Of the four dissociation subtypes, 'depersonalisation' was the primary mediator. Adolescents with chronic patterns of DSH and the 'OD + SI' self-harm type reported more severe dissociation.
Conclusion:
Exposure to abuse significantly increased the risk of DSH in adolescence. This association was mediated by dissociation. Our findings suggest a possible dose-response relationship between dissociation with DSH chronicity and the 'OD + SI' self-harm type, implicating the importance of evaluating dissociation and depersonalisation symptoms as well as abuse exposure in DSH management.
Related Concept Videos
Drug Abuse and Addiction: Pharmacological Phenomena
Cognitive Development During Adolescence
Dissociative Disorders
Dissociative Fugue
A hallmark feature of dissociative disorders is the dissociative fugue...
Dissociative Amnesia
Revisionist Views of Adolescent and Adult Cognition
Erikson's Theory on Socioemotional Development during Adolescence

