Association between nucleotide-binding oligomerization domain protein 2 (NOD2) gene polymorphisms and Parkinson's...

Objective: This study aimed to explore the association between single nucleotide polymorphisms (SNPs) of nucleotide-binding oligomerization domain protein 2 (NOD2) gene and Parkinson's disease susceptibility, including IVS4 + 10A > C (rs72796353) and a missense mutation at exon 9 (c.2857A > G p.K953E). Methods: Rs72796353 and c.2857A > G p.K953E polymorphisms of NOD2 gene were genotyped via polymerase chain reaction-restriction fragment length polymorphism in 125 cases with PD and 120 healthy controls. Genotype and allele frequencies differences of gene polymorphisms between the case and control groups were analyzed by the Chi-square test. Odds ratio (OR) and 95% confidence interval (95%CI) were used to indicate the relative susceptibility to PD. Furthermore, Hardy-Weinberg equilibrium (HWE) was evaluated by the χ² test in controls. Results: Neither genotypes nor allele of rs72796353 was significantly different in cases and control groups (p > .05). Differently, AG/GG genotype of NOD2 2857 A > G polymorphism were associated with the increased risk of PD (OR = 2.486, 95%CI = 1.223-5.056), and G allele carriers were 2.563 times risk to suffer from PD (OR = 2.563, 95%CI = 1.310-5.013). Besides, AG genotype might be also a risk factor for PD. Conclusion: NOD2 c.2857A > G p.K953E polymorphism may be correlated with PD susceptibility in Chinese Han population, but not rs727796353. Further study should be conduct to certify this conclusion.