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Increased free-radical activity during haemodialysis?
Summary
Free-radical activity increased significantly during hemodialysis, indicated by elevated plasma octadeca-9,11-dienoic acid (9,11-LA'). This rise may stem from activated neutrophils and contribute to hemodialysis complications.
Area of Science:
- Nephrology
- Biochemistry
- Clinical Medicine
Background:
- Maintenance hemodialysis is a life-sustaining treatment for end-stage renal disease.
- Oxidative stress and free-radical activity are implicated in various complications associated with hemodialysis.
- Plasma markers are needed to assess free-radical activity during hemodialysis.
Purpose of the Study:
- To investigate free-radical activity in patients undergoing maintenance hemodialysis.
- To measure plasma octadeca-9,11-dienoic acid (9,11-LA"), a marker of free-radical activity, during hemodialysis.
- To explore the potential link between elevated 9,11-LA' and hemodialysis-related complications.
Main Methods:
- Studied 51 patients on maintenance hemodialysis.
- Measured plasma 9,11-LA' (esterified as phospholipids and free fatty acids) at baseline and during hemodialysis.
- Compared patient values to normal control subjects.
Main Results:
- Baseline plasma 9,11-LA' levels in hemodialysis patients were similar to controls.
- A highly significant increase (P < 0.001) in plasma 9,11-LA' was observed in 13 patients during hemodialysis.
- Plasma 9,11-LA' peaked 30 minutes after initiating hemodialysis and subsequently declined.
Conclusions:
- Hemodialysis induces a significant increase in plasma 9,11-LA', suggesting heightened free-radical activity.
- Activated neutrophils may generate the free radicals responsible for the observed rise in 9,11-LA'.
- Abnormal free-radical activity during hemodialysis could contribute to complications like pulmonary dysfunction.