Use of germicides in health care settings-is there a relationship between germicide use and antimicrobial resistance: A concise review
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
David J Weber1, William A Rutala2, Emily E Sickbert-Bennett1
1Department of Hospital Epidemiology, University of North Carolina Hospitals, Chapel Hill, NC; Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, NC.
Abstract:
Despite the widespread use of disinfectants and antiseptics in hospitals, acquired resistance to current disinfectants has rarely been reported. Germicides, as with medications, should only be used when their benefit as demonstrated by scientific studies exceeds possible risks to human health or the environment.
Insights
Acquired resistance to hospital disinfectants is rare despite widespread use. Scientific evidence must demonstrate germicide benefits outweigh risks to human health and the environment before use.
Area of Science:
- Microbiology
- Infectious Diseases
- Public Health
Background:
- Disinfectants and antiseptics are extensively utilized in healthcare settings.
- The emergence of acquired resistance to these agents is a significant public health concern.
Purpose of the Study:
- To evaluate the reported instances of acquired resistance to disinfectants and antiseptics in hospitals.
- To emphasize the importance of risk-benefit assessment for germicide use.
Main Methods:
- Review of scientific literature on disinfectant and antiseptic resistance.
- Analysis of reported cases of acquired resistance in clinical settings.
Main Results:
- Acquired resistance to commonly used disinfectants and antiseptics has been infrequently documented.
- The scientific literature shows limited evidence of widespread disinfectant resistance in hospital environments.
Conclusions:
- The low incidence of acquired resistance suggests current germicides remain effective.
- Germicides should be employed judiciously, with their benefits scientifically validated against potential risks to human health and the environment.
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