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Updated: Jan 24, 2026

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Best products for skin antisepsis.

John M Boyce1

  • 1J.M. Boyce Consulting, LLC, Middletown, CT.

American Journal of Infection Control
|June 1, 2019
PubMed
Summary

Antiseptic skin applications, especially chlorhexidine gluconate (CHG), are crucial for preventing healthcare infections. Evidence supports CHG bathing and alcohol-based solutions for surgical prep, but optimal protocols require further study.

Keywords:
Catheter-related bloodstream infectionsDaily patient bathingPreoperative bathingSurgical hand hygieneSurgical site preparation

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Area of Science:

  • Infection Control
  • Antiseptic Efficacy
  • Healthcare Epidemiology

Background:

  • Antiseptic skin application is vital for preventing healthcare-associated infections.
  • Preoperative bathing and surgical site preparation are key interventions.
  • Current evidence is mixed on the most effective antiseptic protocols.

Purpose of the Study:

  • To review recent evidence on optimal antiseptic products for skin antisepsis.
  • To evaluate the effectiveness of various antiseptic applications in healthcare settings.
  • To identify areas needing further research in antiseptic use.

Main Methods:

  • Review of current scientific literature and clinical evidence.
  • Analysis of studies comparing different antiseptic agents and application methods.
  • Synthesis of data on infection prevention outcomes.

Main Results:

  • Alcohol-based solutions with CHG or povidone-iodine are favored for surgical site preparation.
  • Daily CHG bathing reduces infections in intensive care units (ICUs).
  • CHG-impregnated dressings effectively reduce catheter-associated bloodstream infections (BSIs).

Conclusions:

  • Further trials are needed to compare preoperative bathing methods (soap vs. CHG cloths).
  • Ongoing education and monitoring are essential for effective antiseptic protocols.
  • Surveillance for antiseptic tolerance or resistance is warranted due to widespread CHG use.