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Published on: October 19, 2017
Synthesis of nanostructured Ag@SiO2-Penicillin from high purity Ag NPs prepared by electromagnetic levitation melting
Mahdieh Malekzadeh1, King Lun Yeung2, Mohammad Halali1
1Department of Materials Science and Engineering, Sharif University of Technology (SUT), Azadi Street, Tehran, P.O. Box 11365-9466, Iran.
Abstract:
Nanostructured Ag@SiO2-Penicillin was synthesized from high-purity Ag0 NPs with a mean particle size of about 10 nm produced by electromagnetic levitation gas condensation (ELGC) method. The silver and penicillin contents of the synthesized nano-antibiotic were about 34 wt% and 2.5 wt% respectively, as determined by ICP-OES and TGA analyses. The antibacterial properties and synergistic effects of nanostructured Ag@SiO2 and Ag@SiO2-Penicillin on killing the Methicillin-susceptible S. aureus (MSSA) and Methicillin-resistant S. aureus (MRSA) bacteria were also examined. The nanoparticles were characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM). Ag@SiO2-Penicillin NPs showed an outstanding antibacterial activity compared to Penicillin and Ag@SiO2 NPs. The Fractional inhibitory concentration (FIC) indexes were 0.54 and 0.52 against MSSA and MRSA bacteria respectively, illustrating the synergistic effects of Ag@SiO2-Penicillin NPs. In addition, Ag@SiO2-Penicillin NPs showed promising dose-dependent cytotoxicity effects indicating the protective effects emanating from anti-inflammatory properties of penicillin.
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