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Updated: Jan 24, 2026

In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice
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Wall Contrast Enhancement of Thrombosed Intracranial Aneurysms at 7T MRI

T Sato1,2,3, T Matsushige4,2,5,6, B Chen4,2

  • 1From the Department of Neurosurgery (T.S., T.M., B.C., O.G., P.D., R.J., U.S., K.H.W.) Taku.Sato@uk-essen.de.

AJNR. American Journal of Neuroradiology
|June 1, 2019
PubMed
Abstract

Insights

High-resolution 7T MRI reveals distinct microstructures in thrombosed intracranial aneurysms. Gadolinium enhancement patterns correlate with neovascularization and vasa vasorum, offering insights into aneurysm wall pathology.

Area of Science:

  • Neuroradiology
  • Vascular Imaging
  • Medical Imaging

Background:

  • Pathophysiology of wall contrast enhancement in thrombosed intracranial aneurysms is not fully understood.
  • Investigating aneurysm wall microstructures is crucial for understanding disease progression.

Purpose of the Study:

  • To investigate wall microstructures in thrombosed intracranial aneurysms using gadolinium-enhanced 7T MRI.
  • To correlate in vivo imaging findings with histopathology.

Main Methods:

  • Evaluated 14 thrombosed intracranial aneurysms in 13 patients using 7T MRI.
  • Utilized high-resolution MPRAGE sequences with and without gadolinium contrast.
  • Correlated 7T MRI findings with histopathologic analysis of tissue samples from 5 aneurysms.

Main Results:

  • Inner wall enhancement correlated with neovascularization in the inner wall and adjacent thrombus.
  • Outer wall enhancement linked to vasa vasorum formation in the outer wall.
  • Double-rim enhancement associated with perifocal edema and signs of wall instability.

Conclusions:

  • High-resolution gadolinium-enhanced 7T MRI visualizes two distinct aneurysm wall microstructures.
  • These microstructures are responsible for gadolinium enhancement not seen at lower resolutions.
  • This technique provides in vivo insights into aneurysm wall pathology.

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