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Building bridges to move recombination complexes.

Emeline Dubois1, Arnaud De Muyt1,2, Jessica L Soyer1,3

  • 1Institute for Integrative Biology of the Cell, CNRS, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Université Paris-Sud, Université Paris-Saclay, 91198, Gif-sur-Yvette, France.

Proceedings of the National Academy of Sciences of the United States of America
|June 1, 2019
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Summary
This summary is machine-generated.

Meiosis involves homologous chromosome pairing, facilitated by interaxis bridges that reposition recombination proteins. This process, crucial for genetic diversity, is mediated by the Zip2-Zip4 complex in Sordaria macrospora.

Keywords:
Zip2-Zip4chromosome structureinteraxis bridgesmeiotic recombinationsynaptonemal complex

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Area of Science:

  • Cell Biology
  • Genetics
  • Molecular Biology

Background:

  • Meiosis is essential for sexual reproduction, involving homologous chromosome pairing and recombination.
  • The synaptonemal complex (SC) assembles between paired homologous chromosomes, facilitating crossover formation.
  • Recombination complexes transition from chromosome axes to the SC central region during meiosis.

Purpose of the Study:

  • To investigate the role of interaxis bridges in mediating the transition of recombination complexes during meiosis.
  • To elucidate the function of the Zip2-Zip4 complex in the recombination and SC assembly process.
  • To understand the spatiotemporal localization and molecular interactions of key meiotic proteins.

Main Methods:

  • Microscopic analysis of meiotic progression in the fungus *Sordaria macrospora*.
  • Immunolocalization of recombination proteins (Mer3, Msh4) and SC components (Sme4/Zip1).
  • Analysis of protein complex localization and interactions using genetic and biochemical approaches.

Main Results:

  • Interaxis bridges containing Spo76/Pds5, DNA, Mer3/Msh4, and Zip2-Zip4 mediate the repositioning of recombination complexes.
  • The Zip2-Zip4 complex is released from axes, moves to bridges, and then to the SC central region, dependent on Sme4/Zip1.
  • Zip2-Zip4 exhibits stage-specific affinities for chromosome axes and the SC central element, mediating recombination/structure interface.

Conclusions:

  • The Zip2-Zip4 complex acts as a crucial mediator, facilitating the handoff of recombination complexes from axes to the SC central region.
  • Interaxis bridges are essential structures for SC assembly and proper localization of meiotic recombination machinery.
  • Zip2-Zip4 plays a fundamental role in integrating recombination events with SC formation throughout meiosis.