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Ameliorative effect of tranexamic acid on physiological skin aging and its sex difference in mice

Keiichi Hiramoto1, Yurika Yamate2, Daijiro Sugiyama3

  • 1Department of Pharmaceutical Sciences, Suzuka University of Medical Science, 3500-3 Minamitamagakicho, Suzuka, Mie, 513-8670, Japan. hiramoto@suzuka-u.ac.jp.

Archives of Dermatological Research
|June 1, 2019
PubMed

Insights

Tranexamic acid effectively reduces natural skin aging signs by regulating key molecular pathways. This anti-aging effect was more pronounced in female mice, linked to higher hyaluronic acid synthesis.

Area of Science:

  • Dermatology
  • Biochemistry
  • Aging Research

Background:

  • Natural skin aging lacks effective preventative treatments.
  • Understanding molecular mechanisms driving skin aging is crucial for developing interventions.

Purpose of the Study:

  • To investigate the efficacy of tranexamic acid in mitigating natural skin aging.
  • To explore potential sex-based differences in tranexamic acid's anti-aging effects.

Main Methods:

  • Hairless mice were studied over two years without external stressors.
  • Tranexamic acid was administered orally (12 mg/kg/day) three times weekly.
  • Key molecular pathways involving plasmin, hyaluronic acid, epidermal cells, extracellular matrix (ECM), and matrix metalloproteinases (MMPs) were analyzed.

Main Results:

  • Tranexamic acid administration ameliorated signs of natural skin aging.
  • Inhibition of plasmin synthesis and degradation of ECM via MMP suppression were observed.
  • Reinforced hyaluronic acid synthesis resulted from increased epidermal cells.
  • Sex-dependent differences were noted, with females exhibiting a stronger ameliorative effect.

Conclusions:

  • Tranexamic acid demonstrates potential as a treatment for natural skin aging.
  • The drug acts through regulating plasmin/TGF-β/epidermal cells/hyaluronic acid and plasmin/MMPs/ECM signaling pathways.
  • Female mice showed a superior response to tranexamic acid, correlating with higher hyaluronic acid production.
Keywords:
Extracellular matrixHyaluronic acidNatural agingPlasminTranexamic acidTransforming growth factor-β

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