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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Related Experiment Video

Updated: Jan 24, 2026

Isolation and Purification of Murine Cardiac Pericytes
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Pericytes in Metastasis.

Zalitha Pieterse1, Devbarna Sinha2, Pritinder Kaur3

  • 1Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia.

Advances in Experimental Medicine and Biology
|June 1, 2019
PubMed
Summary
This summary is machine-generated.

Pericytes regulate tumor blood vessel growth and permeability. When pericytes relocate within tumors, they gain new functions that promote tumor growth and metastasis.

Keywords:
CancerCancer cell invasionCancer stem cellsEpithelial-mesenchymal interactionsMesenchymal stem cellsMetastasisOvarian cancerPericytesTumour microenvironmentTumour vasculatureVascular permeability

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Area of Science:

  • Oncology
  • Vascular Biology
  • Cell Biology

Background:

  • Pericytes traditionally support tumor blood vessel stability and regulate permeability.
  • Tumor growth relies on angiogenesis, a process influenced by pericytes.

Purpose of the Study:

  • To review the emerging roles of pericytes beyond vascular stability.
  • To explore how pericyte relocation in the tumor microenvironment alters their function.
  • To highlight pericyte-driven promotion of tumor growth and metastasis.

Main Methods:

  • Literature review of studies on pericyte function in cancer.
  • Analysis of pericyte behavior in the tumor microenvironment.
  • Synthesis of current research on pericyte-mediated angiogenesis, vascular permeability, and metastasis.

Main Results:

  • Pericytes are crucial for maintaining vascular integrity and regulating blood supply in tumors.
  • Pericyte coverage is essential for controlling vascular permeability and preventing tumor cell extravasation.
  • Relocated pericytes acquire pro-tumorigenic properties, actively promoting tumor progression and metastasis.

Conclusions:

  • Pericytes exhibit context-dependent functions in cancer, shifting from vascular support to tumor promotion upon relocation.
  • Understanding these dynamic pericyte roles is critical for developing novel anti-cancer therapies targeting the tumor microenvironment.
  • Further research into pericyte plasticity is warranted to fully elucidate their impact on tumor metastasis.