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Updated: Jan 24, 2026

Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles

Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles

Published on: May 26, 2017

Pericytes in Type 2 Diabetes.

Katherine L Hayes¹

¹Department of Surgery and Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA, USA. katherine.hayes@umassmed.edu.

Advances in Experimental Medicine and Biology

|June 1, 2019

Summary

This summary is machine-generated.

Pericyte cells in blood vessels are damaged by type 2 diabetes, leading to complications like retinopathy and nephropathy. Targeting these pericytes offers a potential therapeutic strategy for diabetic complications.

Keywords:

Advanced glycation end products Beta cell Blood–nerve barrier Blood–retina barrier Dyslipidemia Hyperglycemia Hyperinsulinemia Microvasculature Mural cell Nephropathy Neuropathy Peripheral artery disease Retinopathy

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Area of Science:

Vascular Biology
Endocrinology
Cell Biology

Background:

Pericytes are crucial mural cells supporting microvasculature function.
They regulate blood flow and respond to microenvironmental changes.
Pericytes are vulnerable to metabolic disturbances in type 2 diabetes mellitus.

Purpose of the Study:

To elucidate the role of pericyte dysfunction in type 2 diabetes pathogenesis.
To highlight pericytes as a therapeutic target for diabetic complications.

Main Methods:

The study reviews the physiological roles of pericytes.
It examines the impact of type 2 diabetes metabolic abnormalities on pericytes.
It discusses the link between pericyte dysfunction and diabetic complications.

Main Results:

Type 2 diabetes metabolic abnormalities (dyslipidemia, hyperglycemia, hyperinsulinemia) induce pericyte dysfunction.
Advanced glycation end products, oxidative stress, and other factors contribute to this dysfunction.
Pericyte dysfunction is implicated in diabetic retinopathy, nephropathy, neuropathy, beta cell dysfunction, and peripheral artery disease.

Conclusions:

Pericyte dysfunction is a key factor in the pathogenesis of common type 2 diabetes complications.
Therapeutic strategies targeting pericytes hold promise for treating these conditions.