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Updated: Jan 24, 2026

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes
Published on: June 22, 2016
Monitoring Dendritic Cell Activation and Maturation
Christophe Macri1, Ben Fancke2, Kristen J Radford3
1Department of Biochemistry and Molecular Biology & Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Abstract:
Since the 1997 discovery that the first identified human homolog of Drosophila Toll could activate the innate immune system, the innate arm of immunity has rapidly taken on a new light as an important player in the recognition of pathogens and damaged self. The recognition of danger by dendritic cells (DC) is a crucial step in activating the adaptive immune system. Different DC express varied subsets of pattern recognition receptors (PRR), enabling both overlap and exclusivity in the recognition of danger signals by DC. PRR-mediated DC maturation and activation can be measured by changes in the surface expression of costimulatory as well as coinhibitory molecules, changes in size and shape of the DC and by their production of different cytokines.
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